Complementary Omics Strategies to Dissect p53 Signaling Networks Under Nutrient Stress

Omics of root-to-shoot signaling under salt stress and water deficit.

Maximizing crop yield depends on the leaves receiving an optimal supply of water, mineral nutrients, small organic molecules, proteins, and hormones from the root system via the xylem. Soil drying and salinization alter these xylem fluxes, and modern omics techniques offer unparalleled opportunities to understand the complexity of these responses. Although absolute xylem concentrations of any c...

Integrating Multi-omics Data to Dissect Mechanisms of DNA repair Dysregulation in Breast Cancer

DNA repair genes and pathways that are transcriptionally dysregulated in cancer provide the first line of evidence for the altered DNA repair status in tumours, and hence have been explored intensively as a source for biomarker discovery. The molecular mechanisms underlying DNA repair dysregulation, however, have not been systematically investigated in any cancer type. In this study, we perform...

Social Networks Under Stress

Social network research has begun to take advantage of finegrained communications regarding coordination, decisionmaking, and knowledge sharing. These studies, however, have not generally analyzed how external events are associated with a social network’s structure and communicative properties. Here, we study how external events are associated with a network’s change in structure and communicat...

To dissect or not to dissect?

Mapping paths: new approaches to dissect eukaryotic signaling circuitry

Eukaryotic cells are precisely "wired" to coordinate changes in external and intracellular signals with corresponding adjustments in the output of complex and often interconnected signaling pathways. These pathways are critical in understanding cellular growth and function, and several experimental trends are emerging with applicability toward more fully describing the composition and topology ...